Lab News

Jesse joins the lab!
Hanneke den Ouden Hanneke den Ouden

Jesse joins the lab!

We are happy to welcome a new member to our lab! Jesse (23) is a student at the Cognitive Neuroscience Research Master at Radboud University, Nijmegen. Under the daily supervision of Johannes, he will be working on his Master’s thesis research project where he will look at the neural underpinnings of motivational biases during learning and decision-making processes. For more information, check out his personal page.

Read More
Congrats to Dr. Annelies van Nuland!
Hanneke den Ouden Hanneke den Ouden

Congrats to Dr. Annelies van Nuland!

Annelies van Nuland defended her doctoral thesis on "Molecular, structural, and behavioral differences between tremor dominant and non-tremor Parkinson’s disease". Congrats Annelies!

Read More
Floortje joins the lab!
Hanneke den Ouden Hanneke den Ouden

Floortje joins the lab!

We are welcoming another new member to the lab! After doing a bachelor in Health and Life Sciences and a masters in Cognitive Neuroscience, Floortje is now joining the lab for her PhD, supervised by Hanneke. She will be working on Hanneke’s VIDI project: “Getting things done: Unravelling the neurocognitive mechanisms of adaptive decision-making”, using behavioural paradigms, psychopharmacology and potentially fMRI. Check out her personal page for more information!

Read More
Elena joins the lab!
Hanneke den Ouden Hanneke den Ouden

Elena joins the lab!

Congratulations to Elena for joining the lab! Elena (28) is a new PhD student, working in both Hanneke den Ouden’s lab and Roshan Cools’ lab. She is part of the Language in Interaction consortium, where she investigates the role of cognitive maps and dopamine in linguistic inference, using a combination of functional MRI and psychopharmacology in healthy human volunteers. For more information, check out her personal page!

Read More
New paper in eLife
Hanneke den Ouden Hanneke den Ouden

New paper in eLife

The study “Catecholaminergic modulation of meta-learning” is now published online in eLife. In this study, we examined how the enhancement of catecholamine function modulates the ability to optimise the learning rate as a function of environmental volatility. The results indicate that blocking the catecholamine transporter with methylphenidate enhanced the ability to adapt the learning rate. Specifically, participants showed higher learning rates in volatile relative to stable phases. The paper can be found here.

Read More
New paper by Annelies van Nuland in Human Brain Mapping
Hanneke den Ouden Hanneke den Ouden

New paper by Annelies van Nuland in Human Brain Mapping

Our study “GABAergic changes in the thalamocortical circuit in Parkinson's disease” is now published online in Human Brain Mapping. In this study, we investigated the role of changes in GABA levels in the thalamocortical motor circuit in different clinical phenotypes of Parkinson’s disease. We found that motor cortex GABA levels were negatively correlated with severity of symptoms, both on and off medication. This leads to the conclusion that GABA plays a beneficial role in Parkinson’s disease. The paper is open access and can be downloaded here.

Read More
Congrats to Dr. Jennifer Swart!
Hanneke den Ouden Hanneke den Ouden

Congrats to Dr. Jennifer Swart!

Jennifer Swart elegantly defended her thesis "To go or not to go" and received her doctoral degree cum laude. Congrats Jennifer!

Read More
New paper by Jennifer Swart in PLOS Biology
caius ehmke caius ehmke

New paper by Jennifer Swart in PLOS Biology

Our study titled “Frontal network dynamics reflect neurocomputational mechanisms for reducing maladaptive biases in motivated action” is now published online in the PLOS Biology journal. In this study, we investigated the neurocomputational mechanisms underlying overcoming maladaptive motivational influences through frontal cognitive control. We found that midfrontal theta-band activity covaried with the level of Pavlovian conflict and was associated with reduced Pavlovian biases rather than reduced instrumental learning biases. Motor and lateral prefrontal regions synchronized to the midfrontal cortex, and these network dynamics predicted the reduction of Pavlovian biases over and above local, midfrontal theta activity. The paper is open access and can be downloaded here.

Read More
New paper in the Journal of Cognitive Neuroscience
caius ehmke caius ehmke

New paper in the Journal of Cognitive Neuroscience

Our study titled “Pavlovian Control of Escape and Avoidance ” is now published online in the Journal of Cognitive Neuroscience. In this study, we aimed at establishing a behavioral and computational framework to examine aversive Pavlovian responses (activation vs. inhibition) depending on the proximity of an aversive state (escape vs. avoidance). The results for choice and reaction times suggest that escape is associated with a bias for vigorous action, whereas avoidance is associated with behavioral inhibition. The paper can be found here.

Read More
Mojtaba joins the lab!
Hanneke den Ouden Hanneke den Ouden

Mojtaba joins the lab!

Mojtaba Rostami Kandroodi has joined the lab as a visiting PhD student! He will work with Hanneke on modelling individual differences in reversal learning. For more information, check out his personal page.

Read More
Vanessa joins the lab!
Hanneke den Ouden Hanneke den Ouden

Vanessa joins the lab!

Vanessa Scholz has joined the lab as a postdoctoral guest researcher! She will carrying out a large online study on motivational biases and how they relate to distinct transdiagnostic psychiatric symptom dimensions.

Read More
Johannes joins the lab!
Hanneke den Ouden Hanneke den Ouden

Johannes joins the lab!

We are very excited to be joined by Johannes Algermissen, starting his PhD with us on how we (mal)adaptively employ different decision strategies. For more information, check out his personal page!

Read More
Hanneke awarded 5-yr Vidi Grant by NWO</a>
Hanneke den Ouden Hanneke den Ouden

Hanneke awarded 5-yr Vidi Grant by NWO

Very proud to announce that Hanneke was awarded €800.000 for an NWO Vidi project to study adaptive decision-making under changing environmental constraints. Have a look below for a Dutch and English summary!

Read More
Donders Wonders: Living with Parkinson’s
Hanneke den Ouden Hanneke den Ouden

Donders Wonders: Living with Parkinson’s

In a previous blogpost, Annelies van Nuland described the changes associated with the development of Parkinson’s disease. In her new blogpost, she describes how patients can use treatment to decrease their symptoms. For more, click here [EN] or here [NL].

Read More